Advertisement

HindustanTimes Mon,22 Dec 2014

Peptides can help fight cancer: Expert

Vanita Srivastava, Hindustan Times  Kolkata, January 02, 2013
First Published: 23:12 IST(2/1/2013) | Last Updated: 23:13 IST(2/1/2013)

Biological proteins and peptides can help in the development of drugs that will fight and prevent cancer, said Ananda M Chakrabarty, an Indian-American microbiologist, on the sidelines of the 100th Indian Science Congress — which begins in Kolkata on January 3.

Advertisement

Chakrabarty, who works with the Department of Microbiology and Immunology in the University of Illinois College of Medicine, Chicago, said, “Our work on the biological protein, Azurin, and its derived peptide, P28, could lead to the development of a drug that could fight and prevent the growth of cancerous cells.  Because it is a completely novel approach, the outcome of such research is uncertain at present.  P28 has shown very little toxicity in 15-stage IV terminally ill cancer patients, when no conventional drugs were working. It also showed total regression of tumours in two such patients.”

“We have completed phase 1 of our trials. If P28 is found to be effective in phase 2 and 3 without showing any toxicity, the US Food and Drug Administration will give it market approval. This would take around five years, and the cost would come up to 100 million dollars,” he said. “Making peptide is expensive. Besides that, we also have to pay the cancer patients for letting us conduct the trials.”

Bacterially produced proteins or peptides such as P28 target only cancer cells, thereby showing very little toxicity but significant efficacy. This is the property that makes the bacterial protein drug unique, as compared to other drugs produced by the pharmaceutical industry.


Advertisement
more from Kolkata

BJP-TMC war of words still rages

The war of words between finance minister Arun Jaitley and Trinamool Congress Rajya Sabha MP Derek O’Brien took a new turn on Sunday with BJP’s Bengal in-charge Sidharth Nath Singh alleging that O’Brien was “in his quest to be the King of “Intemperate Vocabulary”.”
Advertisement
Most Popular
Advertisement
Advertisement
Copyright © 2014 HT Media Limited. All Rights Reserved