In the first fallout of the Supreme Court ruling striking down the controversial graft amnesty law, arrest warrants were on Friday issued against Pakistan Interior Minister Rehman Malik.
Defence Minister Chaudhry Ahmed Mukhtar was also barred from going abroad on an official visit.
The National Accountability Bureau, Pakistan's main anti-corruption agency, also banned 250 other officials from going abroad following the order striking down the graft amnesty which benefited over 8,000 politicians and officials.
Judge Mir Muhammad Shaikh of the accountability or anti-corruption court in Karachi issued the arrest warrants against Malik in connection with two graft cases that were closed under the National Reconciliation Ordinance.
The cases relate to alleged misuse of authority and receipt of two cars for ordering a contract to a firm.
The apex court declared the NRO void on Wednesday and directed authorities to reopen corruption and criminal cases against over 8,000 people that were quashed under the law.
The NAB has filed a petition in an anti-corruption court in Rawalpindi for reviving cases against 19 people, including the Interior Minister, that were withdrawn under NRO.
The court's order came hours after Mukhtar, who was leaving for China on an official visit, was barred from boarding a PIA flight late on Thursday night.