The Indians, who had already clinched the series in Mohali by taking an unassailable 3-1 lead, were done in by some poor shots by their top oder batsmen and could never really recover from the early jolts despite Suresh Raina's brilliant effort of 83 under pressure.
Tim Bresnan caused the bulk of the damage with 4/45 while Steve Finn and James Tredwell chipped in with two wickets apiece as the English bowlers exploited the bowler-friendly conditions after winning the toss and putting the home side into bat.
The Indians slumped to a precarious 79 for five as Gautam Gambhir (24), Rohit Sharma (4), Virat Kohli (0), Yuvraj Singh (0) and captain Mahendra Singh Dhoni (15) perished in quick succession with some of them playing atrocious shots.
Raina's brilliant counter-attacking 83 off 98 balls and and some useful contributions from Ravindra Jadeja (39) and Bhuvneshwar Kumar (31) took India to 226.
In their bid to chase down the target of 227, England openers Alastair Cook and Ian Bell started confidently putting in 53 runs before Ishant Sharma, who bowled an incisive first spell, broke the partnership.