The jets were reportedly flown out of the US air base in Okinawa, Japan.
Although it is not the first time F-22s have been used in the annual drill, their presence is sure to further infuriate Pyongyang at a time of sharply escalating military tensions.
North Korea has already threatened to strike the US mainland and US bases in the Pacific in response to the participation of nuclear-capable US B-52 and B-2 stealth bombers in this year's "Foal Eagle" exercise.
On Saturday, North Korea declared it had entered a "state of war" with South Korea and warned Seoul and Washington that any provocation would swiftly escalate into an all-out nuclear conflict.
South Korea and the United States have met the near-daily threats from Pyongyang with their own warnings of severe repercussions, fuelling international concern that the situation might spiral out of control.