It is the experience of the US twins at this level of the competition that helped them blow away the Indo-French pair in the fifth set.
A decisive 3-0 lead early in the final set sealed the match in favour of the Bryans despite a brave fightback from Bopanna and Roger-Vasselin.
In the ninth game when Bob Bryan was serving for the match, Bopanna with a fantastic down the line shot saved a match point but the left-handed Bob served brilliantly to close out on the match on the next match point.
It started well for Bopanna and his French partner as they won the first on tie-breaker at 7-4. Bopanna did hit some booming aces. The Bryans did well to comeback in the next two sets as they broke serve once in the second set and twice in the third set to win them 6-3 and 6-4 respectively.
The Indo-French pair did well to get a break of serve in the fourth set that they won 7-5.
In the decider, the Bryans broke the serve in the second game and held their serve on either side of the break to take a 3-0 lead which sealed the issue.
Sania oustedSania Mirza's Wimbledon journey came to an end on Thursday. Playing the mixed doubles quarterfinals with partner Horia Tecau of Romania, the second seeds failed to defeat the Canadian-French pair of Daniel Nestor and Kristina Mladenovic. The eighth-seeded duo won 7-6(5) 7-6(5) in 106 minutes.
She had earlier lost out in the women's doubles with partner Liezel Huber.