But Muralitharan, who finished his Test career with a record 800 wickets, will not be facing old rival Shane Warne again. The Australian, who had played with the Melbourne Stars, on Monday announced his retirement from the game.
"Murali is still going strong and was our leading bowler last season with 11 wickets," said Renegades chief Stuart Coventry.
"When you have someone like him going for less than six runs an over you expect he'll play a key role again."
Siddle is set to play for the Renegades following the conclusion of the fifth Ashes Test, but there were question marks over Pattinson, who on Monday was ruled out of the remainder of the Ashes with a stress fracture in his back.
Cricket Australia said he would undergo a rehabilitation programme with the aim to have him back for the Australian summer.
"I want to get back into playing short-form cricket," said Siddle.
"To have that opportunity again in four over bursts, having a crack and getting the pace up there ... I think it'll be a lot of fun."
The Big Bash League gets underway in December.