Sensex has lost almost 955 points in the previous five sessions.
On similar lines, the wide-based National Stock Exchange Index, Nifty, declined by 53.80 points, or 0.93 %, to 5,701.25.
Brokers said steady selling by funds on growth concerns after the Reserve Bank of India lowered GDP estimates to 5.5 % from earlier projection of 5.7 % for the current fiscal, dampened the trading sentiment.
Besides, weakening rupee which fell by 60 paise to 61.07 against the dollar in early trade on Wednesday, was another dampening factor, they said.
Meanwhile in the Asian region, Hong Kong's Hang Seng index was up by 0.30 %, while Japan's Nikkei Index was down 0.48 % in early trade.