In his earlier tweets, Perez told his followers why he did not like Applause. He also compared it to Madonna's Girl Gone Wild. Gaga and Madonna famously don't like each other.
In return, Gaga, 27, tweeted how Perez had called her hip injury her 'karma'.
"Still have the text Perez sent me of me in a wheelchair w the words KARMA written across + Madonna pointing a gun at me. Day of my accident (sic)," Gaga added.
Perez has not directly commented on Gaga's tweets but he shared a screenshot of the top singles on iTuainment.