Only 36% of Americans support the kind of military action for what the Obama administration is now seeking Congressional authorisation.
The opposition against such military actions in Syria has been observed across the board.
A total of 54% of Democrats, 55% of Republicans and 66% of political independents say "No" to the US government launching missile strikes against Syrian government, showing deep opposition among every political group.
Americans would express more support for the military actions if Britain and France were to participate, with the support for missile strikes in Syria rising by 10 percentage points to 46 percent.
But the prospect has become less likely after the British parliament voted down a proposal for military intervention in Syria last week.
The US public showed even less support for America and its allies supplying weapons to opposition groups in Syria, with 70% opposing such an action and only 27% supporting.
The poll was conducted by telephone between August 28 and September 1 among 1,012 adults.
The White House is currently trying to win over lawmakers to support military strikes against Syria. Obama Tuesday met Congressional leaders and Secretary of State John Kerry and Secretary of Defense Chuck Hagel appeared at a Senate hearing to make the case for military actions.