The pair played both pace and spin with ease. Masakadza, known for his big shots, played cautiously but was quick to heave an over-pitched delivery from off-spinner Saeed Ajmal for the first six of the Zimbabwe innings.
Mawoyo was dismissed for 13 by left-arm pace bowler Junaid Khan but some resolute batting denied the visiting side another wicket.
Mawoyo played tentatively and edged an outgoing delivery for wicketkeeper Adnan Akmal to take a simple catch.
Earlier, Pakistan failed to add to its overnight score of 249-9 as Ajmal was bowled by pace bowler Tendai Chatara for 49, one short of his career-best score of 50.
Pakistan won a preceding three-game one-day series 2-1 and a two-game Twenty20 series 2-0.