Police said curfew has been imposed in Jinnah Bagh and some other parts of the city after mob went bersek.
"The man accused of blasphemy is a habitual drug addict and the Hindu community in Larkana can't even think of disrespecting any community's religious beliefs," Kalpana Devi, the head of the local Hindu Panchayat, told Geo News.
A local police official said that soon after news spread of the man desecrating the book, angry students and followers of local religious seminaries had started gathering in groups and demanded the man be handed over to them.
"They set on fire the main Hindu temple in the Jinnah Bagh chowk area and also completely gutted the adjoining Dharamsala," the official said.
"Curfew has now been imposed in the area with heavy patrolling by the paramilitary rangers and police who had to baton charge and use tear gas shells to disperse the mob," he said.
Larkana is the hometown of the Bhutto family and the stronghold of the ruling Pakistan People's Party.