Britain now has only two bases operational in Helmand: Camp Bastion, which serves as the main base for UK personnel, and Observation Post Sterga 2.
At the height of the war, Britain had 137 bases in the area.
"The handover and closure of our bases across Helmand underlines the progress UK Forces have made to increase security and stability across the province but also to build up the capability of the Afghan forces who will carry that work forward," said Defence Secretary Philip Hammond.
"Those service personnel who have served in Lashkar Gah and Lashkar Gah Durai and at MOB Price as part of successive UK brigades have made a huge contribution to the campaign which has safeguarded our national security at home."
Hammond pledged Britain's continued support for the Afghan people even after the planned drawdown.
Brigadier James Woodham, Commander Task Force Helmand, said the handover represented "a historic moment in the UK's military campaign in Afghanistan."
"That we are no longer required to operate from these bases is a sign of the progress made by Afghan forces delivering security for their own people," he added.