The property, set in woodlands three miles (five kilometres) outside Dunblane in central Scotland, has undergone extensive refurbishment and tourism officials hope it will prove a big draw for visitors to Scotland.
Murray, 26, envisages the hotel will create up to 40 jobs in Dunblane.
"I'm pleased to be able to give something back to the community I grew up in," he said on the hotel's website.
"By re-establishing Cromlix as a leading luxury hotel at the heart of the Dunblane community we will be able to attract new visitors to the area, create a number of new jobs and focus on supporting other local businesses."
Dunblane was hit by tragedy in March 1996 when resident Thomas Hamilton shot 16 pupils and a teacher dead at the primary school that Murray attended.
Murray, who hid with his brother Jamie under the headmaster's desk during the massacre, still struggles to speak about the experience.
Jamie — a Wimbledon mixed doubles champion — got married at Cromlix House in 2010.
Murray bought the property last year for €1.8 million ($3 million, Rs. 18 crore), according to reports.