Minutes into the second half, a goal from Arjen Robben gave Netherlands the lead against the world champions.
A third scrambled goal from Stephan de Vrij and a second strike from van Persie gave Netherlands a 4-1 lead with less than 15 minutes remaining in the game. Robben struck again to sink the Spanish Armada.
The clash of the 2010 finalists lived up to its billing, as both the teams played an open game.
World Cup Group B: Spain vs Netherlands Live Coverage