Some 54 people have died in or near the capital Accra, and around 300 people are now being infected daily with the highly contagious disease, putting pressure on local health facilities, said Linda Van-Otoo, GHS director for Greater Accra.
"It is not only a health issue, there is a big element of environmental sanitation," she said, adding that local authorities were attempting to tackle the root causes of the disease as well as treat the influx of patients.
Ghana is politically stable but is facing an array of fiscal problems, even though it has sustained economic growth of 8% for five years on the back of its exports of gold, cocoa and oil, making it one of Africa's brightest economies.
President John Mahama's government prides itself on its progress towards meeting United Nations goals for poverty reduction but many people still face a chronic lack of infrastructure and basic services.
Cholera is an acute diarrhoeal illness caused by a bacteria that can cause rapid dehydration and death. Its victims are frequently infected through the ingestion of water and food contaminated by human faeces.
Ghana has recorded no cases of the Ebola virus that since March has killed more than 1,400 people in Guinea, Sierra Leone and Liberia as well as around five people in Nigeria.