Yuvraj was diagnosed with the ailment between his lungs within months of winning the Man of the Tournament award in the 2011 World Cup.
His career looked in jeopardy when the diagnosis was first revealed but the flamboyant all-rounder fought back after undergoing three cycles of chemotherapy in USA.
After a satisfactory rehabilation programme at the NCA, the 30-year-old left-hander will be donning the Team India jersey for the first time post-treatment, and he will surely look to make a statement at the MA Chidambaram stadium.
His last International appearance was the Kolkata Test against the West Indies in November last year, while it was more than a year ago when he last played a T20 (against South Africa on January 9, 2011).
Besides Yuvraj, the match will also mark Harbhajan Singh's return to the squad after a long layoff. The off-spinner had gone out of favour after being blanked 0-4 in the disastrous England tour in July-August last year.
However, with his immediate challenger Ravichandran Ashwin in great form, having taken wickets by the bagful in recent times, chances of Harbhajan being included in the playing XI does not look too bright.
It will be interesting to see if the think-tank goes for an all-offspin attack.