"I am praying that everyone doesn't get sick of us," joked executive producer Steve Levitan.
Homeland, a post 9/11 psychological thriller about a returning Iraq war hero turned by al Qaeda, won best drama after one season on cable channel Showtime. It also took home trophies for best writing and best acting for its two leads, Claire Danes and Damian Lewis, for a total of six including technical awards.
Homeland, said to be one of President Barack Obama's favorite TV programs, brought to an end the reign of AMC's stylish 1960s advertising show Mad Men, which left Sunday's Emmy ceremony empty-handed.
It was the biggest shutout in Emmy history for Mad Men, which had gone into Sunday's awards as joint top nominee with 17 nominations.
Homeland also beat popular Downton Abbey, about aristocrats and their servants in an English country house, and HBO's medieval fantasy series Game of Thrones, in what was the first year that all the nominated best drama series came from cable television.