Berdych, who played a four-hour five-setter on Friday and the doubles rubber on Saturday, got off to a slow start against Ferrer. The 27-year-old Czech lost his very first serve in the first set and then another to let Ferrer, 30, get ahead without too much trouble.
"He (Berdych) played a lot of matches, he played five sets with Nicolas and four sets yesterday," said Ferrer.
"I played very aggressive, I started really good and that was the key," he added, praising his first serve and forehand.
Ferrer broke Berdych's serve early in the second set for a 3-0 lead that prompted Berdych to take a bathroom break.