Obama made the decision to send Clinton after speaking to Egyptian President Mohamed Morsi and Netanyahu late on Monday night, deputy national security advisor Ben Rhodes said.
"Secretary Clinton will emphasise the US interest in a peaceful outcome that protects and enhances Israel's security and regional security," Rhodes said, though stopped short of calling Clinton's trip a mediating mission.
News of Clinton's trip came as Israeli leaders Tuesday discussed an Egyptian plan for a truce with Gaza's ruling Hamas militant group and after the death toll from Israeli raids on the enclave rose to more than 100