"As a result of this suicide attack two civilians have been killed, and 15 civilians and four ISAF soldiers have been injured."
A spokesman for NATO's International Security Assistance Force confirmed the attack, without giving details of any ISAF casualties.
Last week, Taliban suicide attackers struck at a NATO base at Jalalabad airport in eastern Afghanistan, killing five people and wounding several foreign troops in a two-hour battle, officials said.
A total of eight attackers armed with rocket-propelled grenades and automatic weapons were killed, Afghan officials said.
Both assaults came as the summer fighting season should be drawing to a close, indicating that the insurgency remains resilient after surviving the biggest onslaught US-led forces will throw against them.
The last of the extra 33,000 soldiers President Barack Obama deployed in a "surge" nearly three years ago left in September, and the vast majority of the remaining NATO force of more than 100,000 will follow by the end of 2014.