But the effect on the pain experienced varied greatly, they said.
Oxford researchers recruited 12 healthy men to take part in their small study, the BBC News reported.
Participants were given either a 15mg tablet of THC (delta-9-tetrahydrocannabinol) — the ingredient that is responsible for the high — or a placebo.
The volunteers then had a cream rubbed into the skin of one leg to induce pain, which was either a dummy cream or a cream that contained chilli — which caused a burning and painful sensation.