The Bombay Stock Exchange benchmark Sensex on Tuesday opened 36 points lower on profit selling in bluechips like TCS and ICICI Bank.
The 30-share index, which had gained 273.22 points in the previous session, fell by 35.91 points to 17,302.26 points.
The wide-based National Stock Exchange index Nifty also shed 9.15 points to 5,188.55 points.
Marketmen said cautious investors were seen booking profit after a recent surge in fundamentally strong stocks.
Software major TCS fell by over 1 per cent, while ICICI Bank was down by nearly 1 per cent in early trade.
In Asia, Japanese Nikkei was trading 0.38 per cent lower while Hong Kong's Hang Seng Index was unchanged in early trading.