The benchmark Sensex fell over 37 points in early trade on Friday due to sustained selling by funds and retail investors amid a weak trend in other Asian markets.
The 30-share barometer declined by 37.60 points, or 0.18%, to trade at 21,227.58 points. The index had lost 24.31 points in the previous session.
IT, tech, banking and capital goods sector stocks led the fall.
The broad-based National Stock Exchange index Nifty shed 7.10 points, or 0.11%, to 6,311.80 points.
Brokers said sustained selling by funds amid a weakening trend on other Asian bourses in tandem with overnight losses in the US markets, following disappointing corporate results and soft economic data, mainly dampened the trading sentiment.
Besides, investors were cautious ahead of quarterly earnings from Reliance Industries, Wipro and other blue-chip companies to be announced later in the day, they said.
Stocks of IT services major Tata Consultancy Services fell by 3.28% to Rs 2,274.20 despite posting better-than-expected growth of 50.3% in consolidated net profit for the third quarter ended December 2013.
Among other Asian markets, Japan's Nikkei was down 0.69%, while Hong Kong's Hang Seng shed 0.38% in early trade.
The US Dow Jones Industrial Average ended 0.39% lower in Thursday's trade.