The Bombay Stock Exchange benchmark Sensex fell by 93 points in opening trade on Friday, largely on profit booking amid weak trend.
The 30-share barometer, which had gained 65.50 points in Friday's highly choppy session, was trading at 19,837.67 points in early trade, down by 92.97 points from Thursday's close.
Similarly, the wide-based National stock Exchange index Nifty also fell by 31.70 points to 5,967.10 with realty, banking and technology stocks leading the declines.
Brokers said fresh bout of selling by funds and retailers on prevailing levels mainly dragged down the Sensex.
Stocks of Rcom remained under selling pressure on 2G spectrum probe fears and traded 3.83 per cent down at Rs 148.
In other Asian markets, the Hong Kong's Hang Seng index was quoting lower by 1.04%, while Japanese Nikkei was marginally up by 0.61% to trade at five-month high in the morning trade on Friday.
In the US, Dow Jones Industrial Average ended 1.57% higher on stronger-than-expected economic data and hopes for an end to Ireland's debt crisis.