The Bombay Stock Exchange benchmark Sensex declined by 69 points in opening trade on Thursday on continued profit-booking by speculators and other participants.
However, gains on other Asian bourses capped the losses in the domestic market.
The 30-share barometer, which has lost over 89 points in the previous two sessions, declined further by 69.21 points, or 0.33%, to 19,542.99 in the first few minutes of trade on Thursday as auto, IT and banking stocks remained under pressure.
In a similar fashion, the wide-based National Stock Exchange Nifty index slid by 24.35 points, or 0.41%, to 5,874.85 points.
Brokers said continued profit-booking by participants put some pressure on the trading sentiment in the wake of the market rallying by nearly 11% last month, but a better trend on other Asian bourses limited the losses here.
Stocks of the country's largest car-maker, Maruti Suzuki, fell by 1.60% to Rs 1,273.95 on fresh selling after the company recalled 13,157 units of three diesel models.
Meanwhile, Hong Kong's Hang Seng index was up by 0.15% and Japan's Nikkei gained 0.71% in early trade on Thursday. The US Dow Jones Industrial Average ended 0.27% higher in Wednesday's trade.