Novak Djokovic fought back to stun defending champion and seven-time winner Rafael Nadal to claim the Rome Masters 4-6, 6-3, 6-3 on Sunday.
Serbia's world number two Djokovic claimed his third title on the red clay of Rome, having won in 2008 and 2011, the latter with victory over his Spanish rival.
Sunday's win was also Djokovic's 19th career Masters title and his 19th win against Nadal in 41 meetings.
Nadal had been looking to stretch his record of seven titles in the Italian capital.
But despite a dominant first-set display the world number one allowed unforced errors to creep into his game as Djokovic launched a valiant fightback to put himself in pole position to win a first title at the forthcoming French Open.
Nadal admitted three tough matches this week had left his fuel tank empty for the final, but the Spaniard admitted Djokovic had simply been unbeatable on the day.
"He's one of the best in the world, he's playing great," said the Spaniard, who has now lost three matches in the same claycourt season for the first time since 2004.
"I played well for moments, I had my chances for moments, but I could have done with a little more energy at times. My legs didn't answer me after a tough week."
Nadal added: "I was able to find positive things during the tournament but I played three very tough matches this week and it was very hard mentally, as well as physically. I was a little bit tired."
Nadal came into Sunday's final expected to claim an eighth Rome title having won at the Foro Italico every year since 2005 except in 2008 and 2011.
He booked his final ticket with a straightforward win over outclassed 12th seed Grigor Dimitrov of Bulgaria, while Djokovic had been stretched by hard-hitting Canadian Milos Raonic.
It certainly seemed it would be Nadal's day when he broke the Serb twice on his way to a quick 4-1 lead in the opening set, which he went on to win 6-4 as Djokovic made a series of unforced errors.
Djokovic, however, pulled his game together early in the second set, breaking Nadal's serve as early as the second game.
Although Nadal defiantly broke back to 3-2, Djokovic went on to level the contest, taking the second set 6-3.
Djokovic had hit eight forehand and four backhand winners to Nadal's one in the second set, and the Serb carried the momentum into the deciding set, breaking Nadal early for a 2-0 lead.
Nadal pumped his fists when he saved serve in a tightly-contested fifth game and was given more hope when he broke to 3-3 in the next.
But the 27-year-old crucially hit a forehand return long in the next game to hand Djokovic the break and a 4-3 lead.
Djokovic held on to his service game and with Nadal struggling broke the Spaniard again to seal a memorable win.