Ravi Bopara was on Tuesday ruled out of England's two remaining one day internationals against India and this month's Twenty20 World Cup in South Africa with a broken thumb.
Bopara, 22, dislocated and fractured the thumb on his bowling hand in England's defeat in the fifth one dayer at Headingley on Saturday.
England lead the series 3-2 with two matches left to play. The loss of Essex's Bopara is a particularly severe blow because of uncertainty over the availability of his fellow all-rounder Andrew Flintoff.
Lancashire star Flintoff missed the Headingley clash with a recurrence of the ankle problems that have forced him to have three operations in three years, and is doubtful for the sixth match in the series against India at The Oval on Wednesday.
England are due to leave for South Africa on Sunday ahead of the September 12-25 World Twenty20.