Injured fast bowlers Zaheer Khan and Shanthakumaran Sreesanth were on Friday ruled out of India's three-Test series against the West Indies starting later in June.
The pace duo also missed out on the ongoing five-match one-day series in the Caribbean which India are leading 2-0.
"Zaheer has a right ankle problem, and Sreesanth has a right elbow problem. Both players will require some time off for rehabilitation," said N Srinivasan, secretary of the Board of Control for Cricket in India (BCCI).
Abhimanyu Mithun and Praveen Kumar have been named as their replacements in the Test squad.
India are already without Sachin Tendulkar, Virender Sehwag, Gautam Gambhir and Yuvraj Singh for the Test series beginning in Kingston, Jamaica on June 24.
Tendulkar, the world's leading batsman in both Tests and one-dayers, has opted out of the tour in order to spend time with his family while the other players are injured.
India's revised Test squad: Mahendra Singh Dhoni (capt), Venkatsai Laxman (vice-capt), Murali Vijay, Abhinav Mukund, Rahul Dravid, Virat Kohli, Subramaniam Badrinath, Harbhajan Singh, Ishant Sharma, Abhimanyu Mithun, Amit Mishra, Pragyan Ojha, Praveen Kumar, Munaf Patel, Suresh Raina, Parthiv Patel.