Cannabis extract reduces seizures in severe cases of epilepsy, finds study | fitness | Hindustan Times
Today in New Delhi, India
Jun 28, 2017-Wednesday
-°C
New Delhi
  • Humidity
    -
  • Wind
    -

Cannabis extract reduces seizures in severe cases of epilepsy, finds study

A clinical trial of a cannabis derivative shows it cuts down frequency of seizures in patients with especially severe forms of the disorder.

fitness Updated: May 25, 2017 09:05 IST
Cannabis
Researchers used an experimental liquid form of CBD, which has not been approved for use by the US Food and Drug Administration.(Shutterstock)

The first large-scale clinical trial of a cannabis derivative known as cannabidiol shows it was able to cut the frequency of severe epileptic seizures by 39%, say researchers.

Cannabidiol, or CBD, is derived from cannabis plants, but does not cause users to get high. The study in the New England Journal of Medicine comes after years of anecdotal evidence of cannabidiol’s effects. It focused on young patients with Dravet syndrome, a rare form of epilepsy.

“Cannabidiol should not be viewed as a panacea for epilepsy, but for patients with especially severe forms who have not responded to numerous medications, these results provide hope that we may soon have another treatment option,” said lead investigator Orrin Devinsky, professor of neurology, neurosurgery, and psychiatry at New York University Langone Medical Centre.

Researchers used an experimental liquid form of CBD, which has not been approved for use by the US Food and Drug Administration. “We still need more research, but this new trial provides more evidence than we have ever had of cannabidiol’s effectiveness as a medication for treatment-resistant epilepsy.”

A total of 120 children and adolescents, aged two to 18, with Dravet Syndrome were randomised to receive either a placebo or CBD, in addition to their usual treatment. The trial took place at 23 sites in the United States and Europe over the course of 14 weeks.

“Seizure frequency dropped in the CBD-treated group by 39% from a median of nearly 12 convulsive seizures per month before the study to about six,” said the study. “Three patients’ seizures stopped entirely.”

The placebo group saw a much smaller 13% reduction in seizures. Most patients reported side effects, most commonly vomiting, fatigue and fever. A total of 93.4% of patients in the CBD group and 74.6% of those treated with placebo experienced side effects, which were generally reported as mild or moderate.

But eight patients in the CBD group withdrew from the trial because of side effects, compared to one participant in the placebo group.

Follow @htlifeandstyle for more.