Barcelona's treble hopes were hanging in the balance after they were strategically outplayed in a 2-0 defeat by AC Milan in their Champions League last-16 first-leg match on Wednesday.
Second-half goals by Ghanaians Kevin-Prince Boateng and Sulley Muntari left Barcelona with a huge task in the second leg after a night when Lionel Messi was conspicuously quiet for the Catalans.
Barcelona were fuming about the first goal when the ball appeared to strike the hand of Cristian Zapata before it ricocheted into the path of Boateng to fire home in the 57th minute.
There was no doubt about the second, however, as Stephan El Shaarawy lifted the ball up for Muntari to volley past the helpless Victor Valdes with 10 minutes left.
La Liga leaders and Copa del Rey semi-finalists Barcelona, who failed to score for only the second time this season, dominated the first half in typical fashion but struggled to get past Milan's two lines of four defenders.
The Catalans' starting line-up featured 10 players from their youth academy and nine internationals with world and European champions Spain.
They were facing a Milan side patched together during the course of the season after a firesale of top players during the off season to help balance the books.
The contrast was apparent in the first half as Barca passed the ball around with amazing speed and accuracy with an almost telepathic understanding.
Milan's approach was much more haphazard as they struggled to string passes together, lost possession in key areas of midfield and thumped hopeful balls forward.
"The result is what it is. We had the game under control, although admittedly we didn't create too many clear chances and neither did they," Barcelona's interim coach Jordi Roura, standing in for Tito Vilanova who is recovering from throat surgery, told a news conference.
"We hoped we could wear them down. Their first goal was an isolated attack following a shot and a rebound."
"It's a bad result but I'm absolutely convinced that we can turn this around in the second leg with the support of our crowd."
Milan coach Massimiliano Allegri was typically unflappable.
"The boys deserved this result. They didn't give anything away at a defensive level and they made the most of the we had," he said in his usual monotone.
"We made some mistakes in the first half but we improved a lot in the second... the tie is very open."
Milan, who failed to win in their previous seven meetings with Barcelona, fired an early warning shot when Muntari went close with a dipping 30-metre volley which flew over the crossbar after five minutes.
El Shaarawy should have done better when he was sent clear by Kevin-Prince Boateng's flicked pass but failed to control the ball as he raced towards goal, allowing Carles Puyol to intercept.
From the corner, Boateng, who played for Ghana at the 2010 World Cup, hooked the ball just wide of the far post, giving Barca another scare.
Barca, who could have had a penalty when Dani Alves' whipped cross clearly hit Philippe Mexes' outstretched arm, took control with their familiar slick passing.
But they did not create many openings with Messi repeatedly blocked out by a pack of defenders who hounded him every time he got the ball.
The second half started with more Barcelona possession before Milan struck the first blow. A short free kick was played by Riccardo Montolivo, his low shot struck Jordi Alba, ricocheted against Zapata and fell to Boateng to sweep into the goal.
Barca protested furiously, clearly unsettled and the match degenerated into a niggly affair, with the visitors infuriating the crowd at one point by keeping possession after a drop ball.
Andres Iniesta was close to equalising with a shot which swerved wide while an out-of-sorts Messi blasted a free kick high into the stands.
Instead, Milan added another when Muntari sent the 75,000 crowd into raptures with a stunning finish to an excellent move.
"We did not play with our usual fluidity," added Roura. "We did not create the chances we normally create. I don't think it's correct to talk about the referee."
The return leg is on March 12.