Gastric medications may up risk for bacterial infection: Study | health and fitness | Hindustan Times
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Gastric medications may up risk for bacterial infection: Study

The use of gastric acid suppression medications is linked to increased risk of bacterium infection that can cause diseases ranging from diarrhoea to life-threatening colon inflammation.

health and fitness Updated: Mar 28, 2017 16:56 IST
IANS
The researchers analysed gastric suppression medications, which are commonly prescribed for acid reflux disease, peptic ulcer disease or dyspepsia.
The researchers analysed gastric suppression medications, which are commonly prescribed for acid reflux disease, peptic ulcer disease or dyspepsia.(Shutterstock)

People using gastric acid suppression medications may be at a higher risk of bacterium infection that can cause diseases ranging from diarrhoea to life-threatening colon inflammation, researchers have warned.

Infections by Clostridium difficile colitis (C-diff) is caused by disruption of normal, healthy bacteria in the colon, often as a result of antibiotics. The findings suggest that patients who previously had a case of C-diff and receive gastric acid suppressants may be at increased risk of C-diff recurrence.

“The study found that use of gastric acid suppression medications are associated with a statistically significant increased risk of development of recurrent C-diff in patients with a prior episode of C-diff,” said Sahil Khanna, a gastroenterologist at US-based non-profit Mayo Clinic.

For the study, published in JAMA Internal Medicine, the team conducted a systematic review and meta-analysis of 16 studies with 7,703 patients with C-diff and 1,525 of these developed recurrent C-diff.

The researchers analysed gastric suppression medications including proton pump inhibitors, such as omeprazole, and histamine 2 blockers, such as ranitidine, which are commonly prescribed and consumed over-the-counter medications for gastroesophageal reflux disease, peptic ulcer disease or dyspepsia.

The results showed that the rate of recurrent C-diff in patients with gastric suppression was 22.1%, compared to 17.3% in patients without gastric acid suppression. Thus, “it may be reasonable to re-evaluate the need for these medications in patients with C-diff,” Khanna noted.

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