Gut bacteria erects defences against cancer, bowel disease
The presence of bacteria in the human gut could produce substances that protect against colon cancer and provide therapy for inflammatory bowel disease.health and fitness Updated: Feb 10, 2009 17:22 IST
The presence of bacteria in the human gut could produce substances that protect against colon cancer and provide therapy for inflammatory bowel disease.
Researchers from the University of Aberdeen Rowett Institute of Nutrition and Health and from the MTT Agrifood Research Institute in Finland report that bacteria in the gut convert linoleic acid, a naturally-occurring fat in the diet, into a form called conjugated linoleic acid (CLA) which is absorbed by the gut wall.
There are different types of CLA and not all of them have beneficial effects.
"The 'good' form of CLA is present in dairy foods such as milk and cheese," said John Wallace of the Rowett Research Institute, "but eating lots of dairy foods won't necessarily help our gut health as most of the fats are digested in the small intestine before they get to the large intestine, where most of our gut bacteria are found."
The results of these latest studies showed that several different forms of CLA are produced by gut bacteria. Fortunately, most was of the "good" kind, but Wallace stressed that more extensive studies are needed. One subject produced small amounts of a CLA whose beneficial or otherwise effects are much less clear.
The implications are that, if small quantities of dietary linoleic acid can be delivered to the large intestine, the effects on gut health will be generally beneficial in most people, said an Abereen release.
"The results are of special interest for individuals using anti-obesity treatments that prevent the small intestine from absorbing fats. This means that those fats - including linoleic acid - will pass into the large intestine and the gut bacteria will produce CLA. It has to be the correct CLA, so it is important to understand how individuals produce different CLA. This must depend on which types of bacteria are present," Wallace said.
The paper was published in Microbiology.