Ahead of its US debut on Friday,
amassed $201.2 million across 44 countries, outpacing its predecessor's opening weekend take. Variety reports that
raked in $201.2 million after opening in 55% of the international marketplace including France, Italy, Germany, most of Asia including India, the United Kingdom, Russia, Korea and Australia.
Avengers became the third-highest grossing film of all-time, and Age of Ultron, made for $250 million, is expected to match, and possibly surpass, its predecessor's $1.5 billion take at the global box office.
In India, its weekend box office stood at Rs 35.74 crore, over 2.5 times higher than that of Avengers.
Unlike the first film in which the Avengers' battle wreaked destruction without consequences on Manhattan, Age of Ultron shows the super heroes very conscious of the human cost of their war against evil.
In one scene where Iron Man and The Hulk obliterate a skyscraper, the aftermath drew comparisons to the very real destruction in Manhattan during the 9/11 attacks.
"It's a very fine line, and that may be a place we crossed it - we were all worried about that," Whedon said. "At the same time we felt it would be disingenuous to say these guys trashed a city and there's no consequences."
The caped crusaders are back in force in Avengers: Age of Ultron, but this time, the evil they battle is bringing them face to face with the darker consequences of being a super hero.
Age of Ultron, the sequel to Walt Disney Co's 2012 Marvel blockbuster Avengers, will see its star-studded super hero ensemble - Iron Man, Thor, Black Widow, Captain America, The Hulk and Hawkeye - tackle their own fears.
Writer-director Joss Whedon said he wanted to "perform a little open heart surgery" on the Avengers, and "let the audience experience them on a more personal level than they ever have before."
In Age of Ultron, Marvel's super hero worlds come crashing together as the super heroes tackle a complex villain in Ultron (James Spader), spawned out of artificial intelligence and evolving into a megalomaniac.
With help from twins Pietro (Aaron Taylor-Johnson), known as Quicksilver for his super speed, and Wanda (Elizabeth Olsen), the Scarlet Witch with thought-altering magic powers, Ultron makes the Avengers at times turn on themselves.
Robert Downey Jr., Marvel's Iron Man, said given the present day "world stage," now is the time for the Avengers to get real. "This is where you have to actually start dealing with the ramifications of saving the world," he said.
The trend toward somber super heroes has already proved to be a winner at the box office for other studios. The 2013 Superman film Man of Steel, from Time Warner Inc's Warner Bros, made more than $660 million worldwide. The studio's Dark Knight Batman trilogy grossed more than $2 billion globally between 2005 and 2012.
Olsen said Age of Ultron allows audiences to see the "most human versions" of the seemingly invincible Avengers. "It's darker, more emotional and more based on the characters as people, as opposed to super heroes," she said.