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A mixture of five vegetables can prevent strokes

While numerous studies in humans have shown that a high-vegetable diet is associated with a reduced

india Updated: Jun 19, 2006 18:13 IST

While numerous studies in humans have shown that a high-vegetable diet is associated with a reduced risk of cardiovascular disease, as well as with reductions in blood pressure and increases in "good" cholesterol, a new research on animals suggests that increased vegetable consumption may reduce hardening of arteries, thus preventing heart attacks and strokes.

A study in mice found that a mixture of five common vegetables reduced hardening of the arteries by 38 per cent compared to animals eating a non-vegetable diet. "While everyone knows that eating more vegetables is supposed to be good for you, no one had shown before that it can actually inhibit the development of atherosclerosis," said Michael Adams, D.V.M., lead researcher.

"This suggests how a diet high in vegetables may help prevent heart attacks and strokes."

The study used specially bred mice that rapidly develop atherosclerosis, the formation on blood vessel walls of fatty plaques that eventually protrude into the vessel's opening and can reduce blood flow.

The mice have elevated low-density lipoprotein ( LDL), or "bad" cholesterol, which is also a risk factor for atherosclerosis in humans.

Half of the mice in the study were fed a vegetable-free diet and half got 30 percent of their calories from a mixture of freeze-dried broccoli, green beans, corn, peas and carrots.

After almost 4 months, the researchers measured two forms of cholesterol to estimate the extent of atherosclerosis.

In mice that were fed the vegetable diet, researchers found that plaques in the vessel were 38 percent smaller than those in the mice fed vegetable-free diets. There were also modest improvements in body weight and cholesterol levels in the blood.

"Although the pathways involved remain uncertain, the results indicate that a diet rich in green and yellow vegetables inhibits the development of hardening of the arteries and may reduce the risk of heart disease," said Adams.

While Adams hasn't been able to understand exactly how the high-vegetable diet influenced the development of plaques in the artery walls, he said that a 37 per cent reduction in a certain marker of inflammation in mice suggests that vegetable consumption may inhibit inflammatory activity.

"It is well known that atherosclerosis progression is intimately linked with inflammation in the arteries. Our results, combined with other studies, support the idea that increased vegetable consumption inhibits atherosclerosis progression through antioxidant and anti-inflammatory pathways," Adams said.

The research was conducted by Wake.