A new study by geneticists has shown that adaptation, the process by which organisms change to better fit their environment, plays a significant role in human evolution.
For years, researchers have puzzled over whether adaptation plays a major role in human evolution or whether most changes are due to neutral, random selection of genes and traits.
Now, the study by geneticists at Stanford University, US, show that adaptation is indeed a large part of human genomic evolution.
“Others have looked for the signal of widespread adaptation and couldn''t find it. Now we''ve used a lot more data and did a lot of work cleaning it up,” said Dmitri Petrov, associate professor of biology at Stanford University and one of two senior authors of the paper.
“We were able to detect the adaptation signatures quite clearly, and they have the characteristic shape we anticipated,” he added.
All genetic mutations start out random, but those that are beneficial to an organism’s success in their environment are directly selected for and quickly perpetuate throughout the population, providing a uniform, traceable signature.
With the help of post-doctoral researcher James Cai and recent graduate student Michael Macpherson, Petrov and co-senior author Guy Sella, a biologist at the Hebrew University of Jerusalem, used different methodology from what’s been used before to look for signatures of adaptation left in the human genome.
“We detected a number of signatures that suggest adaptation is quite pervasive and common,” Petrov said.
Humans have a very complex history from traveling around the globe, and the human genome is also highly structured, making it complicated and difficult to work with, he said.
To find the adaptation signal, Petrov and his colleagues looked for regions of the genome that “hitchhiked” along with an adaptation.
When a genetic adaptation occurs and is passed on to offspring, other genes on both sides of the adaptation typically accompany it.
The result is a whole region of the genome where all humans are unusually similar to each other, referred to as a “selective sweep,” that researchers can identify and trace through human genetic history.
“Adaptation becomes widespread in the population very quickly,” Petrov said. “Whereas neutral random mutation doesn’t and would not have the selective sweep signature,” he added.
“We tried to see if these regions of unusual similarity among all humans tended to be in particular places in the genome as the theory predicts they should be, and indeed we find them there,” Petrov said.
“The work suggests human beings have undergone rampant adaptation to their environment in the last 200,000 years of history,” he added.