Work has already started on the follow-up to Quantum of Solace starring Daniel Craig as the British spy and one of the film's producers wants the Welsh singer to record the title song.
Producer Michael G. Wilson told Britain's The Sun newspaper: "I would love to get Duffy to sing the next tune. I think she is wonderful. Amy Winehouse would be good too.
"We have started work on the new film, which I can't say anything about. Daniel Craig is very keen to get going."
Back to Black singer Amy Winehouse was due to submit a track for Quantum of Solace with producer Mark Ronson, but sessions were stopped as she reportedly "wasn't ready" to record.
Another Way To Die, performed by Jack White of The White Stripes and soul singer Alicia Keys, was later chosen as the theme song.
Duffy - whose song Mercy picked up the PRS Most Performed Work prize at the Ivor Novello Awards yesterday has revealed she is to make her film debut, although admits she isn't too enthusiastic about it.
She reportedly said: "I'm making a movie. It'll probably be rubbish." If Duffy does sing the theme for the next James Bond film she will be the third Welsh artist to contribute to the spy series, after Tom Jones and Dame Shirley Bassey.