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Excessive oestrogen can cause cancer

EXCESSIVE USE of oral contraceptive pills containing Oestrogen (semi-synthetic) runs the risks of developing ovarian and uterus cancer, according to a research.

india Updated: Nov 09, 2006 14:56 IST

EXCESSIVE USE of oral contraceptive pills containing Oestrogen (semi-synthetic) runs the risks of developing ovarian and uterus cancer, according to a research.

The research was carried out on female albino (white) rats at Pharmacology & Toxicology Department of College of Veterinary Science and Animal Husbandry, Jawaharlal Nehru Krishi Vishwa Vidyalaya (JNKVV) here.

Researcher Madhuri Sharma, a lecturer in the college carried out the research on nearly 36 rats feeding them oestrogen orally for six months. She was guided by Dr Govind Pandey, HoD Pharmacology Sri Ram Institute of Technology, Prof Y P Sahni, HoD, Pharmacology & Toxicology, Government Veterinary College; and Prof Asha Khanna HoD, Zoology Model Science College.

According to Ms Sharma, the rats were divided into six groups of equal numbers and administered oestrogen used in the oral contraceptive pills. The rats were sacrificed to find out the effect, which were very alarming.

She said that in the first month, some rats, which were administered heavy dose of Oestrogen, developed dullness, deep breathing, in-coordination in gait, loss of appetite and slow weight gain with paralytic effect. This suggested that higher dose and prolonged administration of Oestrogen could cause much toxicity and may also change the normal anatomy and histology of the body organs.

Sharma said that in the following months, cytotoxic effect on Uterus and Ovary were found besides adverse effects on breast and liver. She said that in the last month, all the six rats had ovary or uterus cancers (carcinogenic cells).
Sharma had presented her research paper at International Conference on Toxicology, Toxicogenomics and Occupational Heath at School of Studies in Zoology Jiwaji University, Gwalior last month.

Her research on rats had won her ‘best paper’ award at National Symposium on Recent Advances in Veterinary Anatomy and their Applications to Improve Livestock Health, Production and Reproduction at College of Veterinary Science and Animal Husbandry, JNKVV, Jabalpur.  Meanwhile, Sharma along with her seniors is working on herbal treatment of the rats with cancer at the College of Veterinary Science here.

According to Dr Govind Pandey, William A. Meissner, Sheldon C Sommers and Gwendolyn Sherman carried out a research on rabbits in England in the 50s in which they had used diabetic rabbits. They had fed Oestrogens (stilbestrol) to those rabbits and detected cancer in them after sometime.

Dr Pandey said that oral contraceptive pills became common in US in 60s and according to a survey half the women population in the world use oral contraceptive pills. The US government, acting on the report of its National Toxicology Programme, has banned excessive use of oestrogen.