World junior runner up Saina Nehwal, national champion Anup Sridhar, and his predecessor Chetan Anand all bowed out after losing to their fancied rivals.
While 16-year-old Saina and Sridhar went down after a tough fight against Eriko Hirose of Japan and Ponsana Boonsak of Thailand, Anand was routed by fourth-seeded South Korean rival Lee Hyun Il.
Pitted against Hirose, the fifth seed, Hyderabad girl Saina fought hard in an extremely close opening game in which she saved four game points but then ran out of steam to suffer a 23-25, 7-21 defeat in 34 minutes.
In the men's category, Bangalore-based Sridhar fought back from an opening game reversal to level things before sixth seed Boonsak regained his composure to triumph 21-17, 19-21, 21-16 in 53 minutes.
In contrast to Saina and Anup, Anand had no answer to the quality of play exhibited by fourth seed Lee, who took just eighteen minutes to dispose of the Indian 21-6, 21-9 and storm into the quarter finals.