Neanderthal genome project launched | india | Hindustan Times
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Neanderthal genome project launched

india Updated: Jul 29, 2006 16:30 IST

US and German scientists launched a two-year project to decipher Neanderthals’ genetic code, a feat that they hope will help deepen understanding of how modern humans’ brains evolved.

Neanderthals were a species of the Homo genus who lived in Europe and western Asia from more than 200,000 years ago to as little as roughly 30,000 years ago.


Cracking the gene code

• Over a period of two years, the scientists aim to reconstruct a draft of the 3 billion building blocks of the Neanderthal genome – working with fossil samples from several individuals

• They face the complication of working with 40,000-year-old samples, and of filtering out microbial DNA that contaminated them after death

• About 5 per cent of the DNA in the samples is actually Neanderthal DNA, estimate scientists, but they added that pilot experiments had convinced them that the decoding was feasible

Scientists from Germany’s Max Planck Institute for Evolutionary Anthropology are teaming up with Branford, Connecticut-based 454 Life Sciences to map the Neanderthal genome, or DNA code.

“The Neanderthal is the closest relative to the modern human, and we believe that by sequencing the Neanderthal we can learn a lot,” said Michael Egholm, the vice-president of molecular biology at 454, which will use its high-speed sequencing technology in the project.

There are no firm answers yet about how humans picked up key traits such as walking upright and developing complex language. Neanderthals are believed to have been relatively sophisticated, but lacking in humans’ higher reasoning functions.

The Neanderthal project follows scientists’ achievement last year in deciphering the DNA of the chimpanzee, our closest living relative, which produced a long list of DNA differences with the chimp and some hints about which ones might be crucial.

The chimp genome “led to literally too many questions, there were 35 million differences between us and chimpanzees – that’s too much to figure out,” said Jonathan Rothberg, 454’s chairman.