Health Minister Anbumani Ramadoss and Minister of State for Railways R Velu on Saturday resigned from the union council of ministers, two days after the PMK quit the Congress-led ruling coalition.
"Velu and myself have submitted our resignation from the council of ministers to the honourable prime minister," Ramadoss told reporters here.
"The prime minister said he will be forwarding the letters to the president with a heavy heart.
"We explained to the prime minister the circumstances... the problems we are facing with the DMK in Tamil Nadu," added Ramadoss, whose party walked out of the United Progressive Alliance (UPA) two days ago.
In Chennai earlier Saturday, the AIADMK and PMK announced a seat-sharing formula under which the PMK would contest six Lok Sabha seats in Tamil Nadu and one in Puducherry.