Jamia Milia Islamia has been shut indefinitely following violence on the campus over admissions, in which five persons were injured.
"We have shut down the university indefinitely," University Vice Chancellor Mushirul Hasan told PTI in New Delhi.
Students have also been asked to vacate the hostel within two days, he said.
Students of the University allegedly went on a rampage on Tuesday and damaged some offices as also several vehicles parked in the campus after being denied a meeting with the Vice Chancellor.
They had sought the meeting with Hasan apparently over the issue of denial of readmission to students whom the varsity officials had identified as 'known trouble makers' and rusticated by the previous Vice Chancellor.
"These students have various cases registered against them with the police and they want to infiltrate the students union which has been revived by me. But I will ensure that no one gets in," Hasan said.
Students also held up traffic on the Mohammad Ali road adjoining the University and police were called in to disperse the crowd. Five persons were injured in the fracas.
Terming as a 'shameful act of vandalism' the rampage by a group of 10-20 students, Hasan said such behavior 'will not be tolerated'.
Dismissing allegations by the students that they were beaten up in his chamber, Hasan said "these are mere cooked up stories to show that they are innocent."