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HindustanTimes Sat,20 Sep 2014

Obesity could be linked to microorganisms living in gut

ANI  Washington, March 28, 2013
First Published: 13:08 IST(28/3/2013) | Last Updated: 13:10 IST(28/3/2013)

People, who have high concentrations of both hydrogen and methane gasses in their breath, are more likely to have a higher body mass index (BMI) and higher percentage of body fat, researchers led by an Indian-origin have claimed.

“This is the first large-scale human study to show an association between gas production and body weight – and this could prove to be another important factor in understanding one of the many causes of obesity,” lead author Ruchi Mathur, MD, director of the Diabetes Outpatient Treatment and Education Center in the Division of Endocrinology at Cedars-Sinai, said.

The study analyzed the breath content of 792 people and based on the breath tests, four patterns emerged: the subjects either had normal breath content, higher concentrations of methane, higher levels of hydrogen, or higher levels of both gases.

Those who tested positive for high concentrations of both gases had significantly higher body mass indexes and higher percentages of body fat.

The presence of methane is associated with a microorganism called Methanobrevibacter smithii, organism responsible for the majority of methane production in the human host.

“Usually, the microorganisms living in the digestive tract benefit us by helping convert food into energy. However, when this particular organism– M. smithii – becomes overabundant, it may alter this balance in a way that causes someone to be more likely to gain weight,” Mathur said.

These organisms scavenge hydrogen from other microbes and use it to produce methane – which is eventually exhaled by the host. Researchers theorize this interaction helps neighbouring hydrogen-producing bacteria thrive and extract nutrients from food more efficiently. Over time, this may contribute to weight gain.

“Essentially, it could allow a person to harvest more calories from their food,” Mathur said.

In an ongoing study, participants who have evidence of methane on their breath are given a standard diet over three days, undergo an oral glucose challenge, and swallow a “smart pill” to track how fast the food moves through their bodies.

In addition, their stool is collected and sent for calorie analysis allowing researchers to determine how many calories are being harvested during digestion. Participants then repeat the same tests after taking the antibiotic regimen to see if elimination of the organism results in measureable changes.

The study has been published online on The Endocrine Society’s Journal of Clinical Endocrinology and Metabolism.


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