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HindustanTimes Wed,30 Jul 2014

Soon, jab to ward off flu before it gets you sick

ANI  Washington, July 07, 2012
First Published: 12:32 IST(7/7/2012) | Last Updated: 14:35 IST(7/7/2012)

In a new study, researchers may have found the secret to helping the immune system fight off the flu before it gets you sick.

The new study has found that EP67, a powerful synthetic protein, is able to activate the innate immune system within just two hours of being administered.

Prior to this study, EP67 had been primarily used as an adjuvant for vaccines, something added to the vaccine to help activate the immune response.

But Joy Phillips, a lead author of the study with her colleague Sam Sanderson, Ph.D. at the University of Nebraska Medical Center, saw potential for it to work on its own.

“The flu virus is very sneaky and actively keeps the immune system from detecting it for a few days until you are getting symptoms,” Phillips said.

“Our research showed that by introducing EP67 into the body within 24 hours of exposure to the flu virus caused the immune system to react almost immediately to the threat, well before your body normally would,” she said.

Since EP67 doesn’t work on the virus but on the immune system itself, it functions the same no matter the flu strain, unlike the influenza vaccine which has to exactly match the currently circulating strain.

Phillips said while this study focuses on the flu, EP67 has the potential to work on other respiratory diseases and fungal infections and could have huge potential for emergency therapeutics.

“When you find out you''ve been exposed to the flu, the only treatments available now target the virus directly but they are not reliable and often the virus develops a resistance against them,” he said.

“EP67 could potentially be a therapeutic that someone would take when they know they’ve been exposed that would help the body fight off the virus before you get sick,” Phillips said.

It could even be used in the event of a new strain of infectious disease, before the actual pathogen has been identified, as in SARS or the 2009 H1N1 influenza outbreak, Phillips said.

Right now, the testing has been done primarily in mice by infecting them with a flu virus. Those that were given a dose of EP67 within 24 hours of the infection didn’t get sick or as sick as those that were not treated with EP67.

The study has been recently published in the Public Library of Science journal PLoS ONE.


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