U2's gig at the Pasadena Rose Bowl in California on Sunday will be streamed live on YouTube, the band have announced.
Fans in 16 countries, including the UK, the US, Australia and India, will be able to watch the show at 0330 GMT. Clips from the concert would be available on the site after the gig ends.
It will be the biggest concert ever streamed on the video-sharing Web site.
The site will also offer viewers the ability to chat to one another using Twitter, or to give money to Bono's RED charity via a "donate now" button, while they watch the show.
"U2 had wanted to do something like this for a long time," Paul McGuiness, manager of the popular rock band said. "Fans often travel long distances to come to see U2 - this time U2 can go to them, globally," he added.
YouTube has also experimented with live broadcasts in the past, most notably with its YouTube Live show, which premiered on 22 November, 2008 with performances from will.i.am and Katy Perry.