Bayern in second place with eight games remaining.
If Juergen Klopp's side fail to win at Stuttgart on Saturday afternoon, record champions Bayern will be in a position to clinch their 23rd national title, and 22nd since the inception of the Bundesliga half a century ago.
However, it is inevitable that the Bavarians will eventually get their hands on the 'Salad Bowl' trophy, and those at the club are not too concerned whether they do so this weekend, especially with the first leg of their Champions League quarter-final against Juventus to come on Tuesday.
Bayern players and staff insist all the focus is on Hamburg, but the prospect of any major celebrations if they do wrap up the title has been ruled out, with officials confirming that there will be no trophy presentation at the Allianz Arena regardless of what happens.
"In the dressing room, we're talking exclusively about Hamburg," said midfielder Bastian Schweinsteiger. "That's our main focus. We need a good performance."
"Obviously it would be an incredible moment but one we'd only be able to savour very briefly," sporting director Matthias Sammer told Bild of the possibility of wrapping up the championship. "Preparation for the Juventus match will start immediately with a meal together at the stadium."
Bayern against Hamburg is a meeting of the traditional giants of southern and northern Germany, but while Bayern have long dominated the country's footballing scene, HSV are struggling to keep up.
In the last two campaigns, Bayern have won this fixture 6-0 and 5-0, and it is 26 years since Hamburg last won a trophy, but the side coached by one-time Bayern star Thorsten Fink still have plenty of motivation.
Just a point adrift of the top four, they are one of several clubs still in in contention for a place in the Champions League next season. "Maybe some of them will be thinking about Juve," said Dutch international midfielder Rafael Van der Vaart. "But Bayern want to wrap up the Bundesliga title as soon as possible."
Ready for battle
Milan: Juventus striker Mirko Vucinic insists the champions will not take Inter Milan lightly when the sides meet in the much-anticipated Derby d'Italia on Saturday.
Juve top the Serie A table with a nine-point lead on Napoli with Milan in third, a further two points back with nine games remaining in the campaign.
Inter's solid first half of the season has been replaced by inconsistency in recent months and although in fifth place Andrea Stramaccioni's side are seven points behind Milan and the third and last Champions League qualifying spot.
Vucinic says Juve will be treating the clash like the "last game of their lives". "We're playing against Inter, the name says it all," he said.