Spectators were out in force as the superstar squad, wearing suits with trainers, arrived by chartered jet at Bangkok's Don Mueang Airport, where David Moyes performed a traditional Thai greeting.
The players then boarded a huge bus emblazoned with the words "United in Thailand" and drove to their five-star downtown hotel, where they were welcomed by more fans holding banners and scarves.
Moyes and United great Ryan Giggs were also mobbed during a visit to Siriraj hospital, where they paid their respects and brought a big bunch of flowers for Thailand's revered king and queen, who are both unwell.
England striker Wayne Rooney, at the centre of intense speculation about his future, walked with his head down and did not talk to media as he arrived with his team-mates.
David Moyes and Ryan Giggs stand next to images of Thai King Bhumibol Adulyadej and Queen Sirikit in Bangkok. AFP
"It's crazy whenever we visit this part of the world," defender Rio Ferdinand told the club's website. "The reception we get in the Asian countries is something else entirely. I've never seen fanatics like them.
"They come to airports at mad times in the morning to greet us, they hang around our hotels... it's great and makes us feel really welcome."
Manchester United are the first to arrive in what will be a bumper Asian pre-season, with Chelsea also due in Bangkok this week and Barcelona, Manchester City and Liverpool among the other clubs headed to the region.
Man United fans wait to get autographs at the Four Seasons hotel in Bangkok as the club begins its new era under boss David Moyes. AFP
Moyes, taking over after Alex Ferguson's 27-year, 38-trophy career at the club, will lead out the team for the first time against a Thai All-Star XI in Bangkok on Saturday.
Captain Nemanja Vidic stayed in Manchester because of back pain, but he may join the 19-man squad later on the tour of Thailand, Australia, Japan and Hong Kong, according to the club website.
Robin van Persie, David De Gea and Shinji Kagawa will also meet up with the team later but Javier Hernandez, rested after international duty, and injured trio Chris Smalling, Ashley Young and Nani are all missing.
Exciting new signing Wilfried Zaha is one prominent inclusion and veteran defender Ferdinand said all players were keen to make an early impression on the new boss.
"I think it's natural that everybody here is trying to impress on this tour," he said.
"When you get a new manager you want to show him that you should be in the starting XI for that first day of the new season and that process has started already."
But the tours are likely to be dominated by transfer talk with British media reporting that Chelsea, who arrive in Bangkok on Friday, are preparing a major bid for Rooney.
However, Moyes has signalled his determination to keep the striker, who asked for a transfer in May, by describing his concerted effort to win over the want-away star.
Rio Ferdinand uses a video camera as he arrives at Don Muang International airport in Bangkok. AFP
"I have met Wayne two, three, four times," Moyes, who coached Rooney when they were both at Everton, told Britain's talkSPORT radio.
"A lot has been said about myself and Wayne over the years but we have a really good relationship. He came to my house, I have been to his recently to have a chat."
Moyes, who looks set to lose out on a bid to sign Barcelona midfielder Thiago Alcantara, also insisted the club were "working hard" to buy new players as they seek to defend their Premier League title.
Chelsea will also play their first game under returning manager Jose Mourinho in Bangkok next week, while Manchester City will be under new boss Manuel Pellegrini when they play a mini-tournament in Hong Kong.
A ManU fan takes video with her mobile phone as her favorte team bus leaves Don Muang airport in Bangkok. AP
Barcelona and Liverpool are also among the visitors in the coming weeks to a region which comprises the bulk of the world's population and contributes growing revenues to top clubs via TV rights and merchandise.
Zaha to play a part in Man United's Asia tour
England winger Wilfried Zaha will play a part in Manchester United's pre-season tour of the Far East and Australia, manager David Moyes said.
The Ivory Coast-born 20-year-old, the final signing by Moyes' predecessor Alex Ferguson before his retirement, joined the Premier League champions this week for his first training session.
United have in the past loaned out promising youngsters to other sides to gain experience and there has been speculation that Zaha, who has yet to play in the Premier League, might return for a spell at previous club Crystal Palace.
"He will travel with us on the tour," he told talkSPORT radio before United's departure to Thailand for a tour that starts in Bangkok on Saturday.
"He has only been with us for two days but I will take him away, see how he goes and have a look. This club has a great record of putting young players in the team. Hopefully Wilfried can be one of them." Read more
"You get to see what the club means to the fans by the fantastic reception we’re given everywhere we go" - @carras16 #mutour