Maria Sharapova's impressive sequence of French Open results ended when the defending champion was knocked out 7-6 (3), 6-4 by 13th-seeded Czech Lucie Safarova in the fourth round on Monday.
Sania Mirza and Martina Hingis won their third round match to progress to the quarter-finals, while the Paes-Nestor and Bopanna-Mergea teams were knocked out.
Following a rain-hampered Sunday schedule, Monday's action will feature all four members of The Big Four vying for quarter-final spots, as well as the likes of Serena Williams and Maria Sharapova.
No Frenchman has won at Roland Garros since Yannick Noah in 1983. Tsonga's next opponent in the journey to the title would be Japan's fifth-seeded Kei Nishikori.
Roger Federer bids to reach the French Open quarterfinals for the 11th time on Sunday when he faces home favourite Gael Monfils.
Indian tennis veteran Leander Paes and his Swiss partner Martina Hingis crashed out of the French Open after losing in the mixed doubles pre-quarterfinals in Paris.
Serena Williams' survival instincts dug her out of trouble against a familiar foe on Saturday after Novak Djokovic and Andy Murray slapped down pesky Australian upstarts on day seven of the French Open.
The 28-year-old Russian is no stranger to the challenges of being a child prodigy, having won Wimbledon in 2004 at the age of 17.
After fighting through a cold, windy conditions, and a tricky opponent, the Russian was visibly relieved to progress through to the fourth round of the women's singles draw.
Leander Paes, Rohan Bopanna, and Sania Mirza won their respective second-round doubles matches on Friday.
The top seeds in the men's singles and women's singles draws, as well as the nine-time champion, will look to seal their fourth round spots in Saturday's action.
The Frenchman Gael Monfils pulled off a stunning comeback to recover from a two sets to one deficit and down a double break in the fourth set.
Indian tennis aces Leander Paes and Sania Mirza won their respective matches to advance to the third round of the French Open in Paris on Friday.
Paes-Hingis progressed to the second round, while Bopanna-Shvedova lost a tight match and top seeds Mirza-Soares were upset.
Paes achieved the milestone after winning first round match with his 99th career partner Daniel Nestor at the French Open on Wednesday. Paes has become the eight player in ATP tour history to achieve the feat, joining the Bryon brothers, Todd Woodbridge and Mark Knowles among others.