Arsenal's players are aiming to expose out-of-form Marseille to the same attacking football that blew away Chelsea when the teams meet in the Champions League on Tuesday.
With Borussia Dortmund hosting Olympiakos in the other Group F match, leader Arsenal can move to the verge of a second-round place with victory. But the Gunners want another sparkling attacking display to go along with three points.
Arsenal continued its recovery from a terrible start to the season with a 5-3 win at Chelsea on Saturday, and manager Arsene Wenger says "the players are determined together and they want to play like we did against Chelsea."
With 28 goals in 27 Premier League matches in 2011, Robin van Persie will again lead the Arsenal attack.