Manchester City surrendered their 100% start to the Premier League season as Fulham fought back from two goals down to draw 2-2, while Tottenham routed nine-man Liverpool 4-0 on Sunday.
Roberto Mancini's side, who had won their first four matches, moved to the top of the table with their draw, one point above Manchester United ahead of the champions' clash against Chelsea later on Sunday, but left Craven Cottage disappointed after a second half meltdown.
Sergio Aguero has been in sublime form since joining City from Atletico Madrid for a club record £38 million in pre-season and the Argentina forward fired the visitors into the lead as he met David Silva's pass with a clinical finish in the 18th minute.
Aguero seemed to have put City in total command when he steered home Edin Dzeko's flick in the 46th minute for his eighth goal of the season.
But Bobby Zamora got one back for Fulham in the 55th minute with a curling shot from the edge of the area and Danny Murphy completed the fightback when his long-range shot deflected in off Vincent Kompany in the 75th minute.
At White Hart Lane, Harry Redknapp's Tottenham took the lead early in the first half through Luka Modric's superb strike before Liverpool duo Charlie Adam and Martin Skrtel were sent off either side of half-time.
Jermain Defoe made it 2-0 and Togo striker Emmanuel Adebayor, on loan from Manchester City, struck twice to take his tally for the club to three in two games.
The defeat was the heaviest suffered by Liverpool boss Kenny Dalglish since he began his second spell in charge in January, as well as the biggest Spurs success against the Reds since 1963.
Tottenham took the lead in the seventh minute when Croatia midfielder Modric slammed a blistering shot into the top corner of Pepe Reina's goal.
Scottish midfielder Adam was dismissed in the 28th minute after earning a second booking with a foul on Scott Parker.
Any thoughts that Liverpool could still avoid a second successive defeat were erased when Skrtel was sent off in the 63rd minute for a second booking after clattering Gareth Bale.
Tottenham took full advantage of their numerical superiority. Defoe ran clear to score in the 66th minute and Adebayor tapped in after Reina spilled Defoe's shot two minutes later before blasting home from close-range in stoppage time.
At the Stadium of Light, Sunderland stormed into a three-goal lead before half-time against Stoke and eventually ran out 4-0 winners.
Titus Bramble got the first goal in the fifth minute when Stoke goalkeeper Asmir Begovic fumbled the defender's shot over the line and an own goal from Jonathan Woodgate increased the lead in the 11th minute.
Craig Gardner netted the third in the 28th minute and Sebastian Larsson emphasised Sunderland's dominance when his free-kick beat Begovic in the 58th minute.