Novak Djokovic’s bid to become the first man in 43 years to hold all four Grand Slam titles at the same time hit its first hurdle on Friday when Roger Federer became a potential French Open semi-final opponent.
In stark contrast, defending champ Rafael Nadal, bidding for an historic seventh title, was left with a more comfortable passage with third seed Andy Murray as a possible semi-final rival.
Djokovic starts against Italy’s Potito Starace and could face Australia's Lleyton Hewitt, playing in Paris on a wildcard, in the second round.
Adding spice to the top half of the draw is Argentine Juan Martin del Potro.
Serena Williams and Maria Sharapova could meet in the French Open quarterfinals.
The other possible quarterfinals set up are Victoria Azarenka vs. Sam Stosur; defending champion Li Na vs. Petra Kvitova; and No.3-seeded Agnieszka Radwanska vs. No. 8 Marion Bartoli.